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Ephedra for Weight Loss?
What is Ephedra, Ephedrine and Ma Huang?
The Chinese herb ma huang is a member of a primitive family
of plants that look like thin, branching, connected straws. A
related species, Ephedra neva-densis, grows wild in the American
Southwest and is widely called "Mormon tea." However,
only the Asian species of ephedra contains the active compounds
ephedrine and pseudoephedrine.
Ma huang was traditionally used by Chinese herbalists during
the early stages of respiratory infections and also for the
short-term treatment of certain kinds of asthma, eczema, hay
fever, narcolepsy, and edema.
Japanese chemists isolated ephedrine from ma huang at the
turn of the century, and it soon became a primary treatment for
asthma in the United States and abroad. Ephedra's other major
ingredient, pseudoephedrine, became the decongestant Sudafed.
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The U.S. Food and Drug Administration (FDA)
advises consumers to stop using dietary
supplements containing ephedra. In order to
protect consumers, the FDA published a final
rule on April 12, 2004, that bans the sale of
dietary supplements containing ephedrine
alkaloids.
After a careful review of the available
evidence about the risks and benefits of ephedra
in supplements, the FDA found that these
supplements present an unreasonable risk of
illness or injury to consumers. The data showed
little evidence of ephedra's effectiveness,
except for short-term weight loss, while
confirming that the substance raises blood
pressure and stresses the heart. The increased
risk of heart problems and strokes negates any
benefits of weight loss.
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The FDA reviewed information about ephedra's
pharmacology, studies of its safety and effectiveness, newly
available adverse event reports, and the RAND Corporation
report--a review of the published scientific literature on
ephedra efficacy and safety, sponsored by NCCAM and the National
Institutes of Health's Office of Dietary Supplements. In
addition, the FDA considered additional recent studies
confirming that ephedra use raises blood pressure and otherwise
stresses the circulatory system. In February 2003, the agency
solicited public comments regarding ephedra's side effects and
whether ephedra-containing dietary supplements pose a
"significant or unreasonable risk of illness or
injury."
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